9-Norlignans: Occurrence, Properties and Their Semisynthetic Preparation from Hydroxymatairesinol

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Patrik Eklund P, Jan-Erik Raitanen
Förläggare: MDPI
Publiceringsår: 2019
Tidskrift: Molecules
Tidskriftsakronym: MOLECULES
Volym: 24
Nummer: 2
Antal sidor: 12
ISSN: 1420-3049
eISSN: 1420-3049


Abstrakt

Lignans, neolignans, norlignans and norneolignans constitute a large class of phenolic natural compounds. 9-Norlignans, here defined to contain a -' bond between the two phenylpropanoid units and to lack carbon number 9 from the parent lignan structure, are the most rarely occurring compounds within this class of natural compounds. We present here an overview of the structure, occurrence and biological activity of thirty-five 9-norlignans reported in the literature to date. In addition, we report the semisynthetic preparation of sixteen 9-norlignans using the natural lignan hydroxymatairesinol obtained from spruce knots, as starting material. 9-Norlignans are shown to exist in different species and to have various biological activities, and they may therefore serve as lead compounds for example for the development of anticancer agents. Hydroxymatairesinol is shown to be a readily available starting material for the preparation of norlignans of the imperanene, vitrofolal and noralashinol family.


Nyckelord

9-norlignans, bioactivity, norlignans, semisynthesis

Senast uppdaterad 2020-27-05 vid 04:28