Therapeutic Potential of Polymer-Coated Mesoporous Silica Nanoparticles

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Kuldeep K. Bansal, Deepak K. Mishra, Ari Rosling, Jessica M. Rosenholm
Publisher: Multidisciplinary Digital Publishing Institute
Publication year: 2020
Journal: Applied Sciences
Volume number: 10
Issue number: 1


Abstract

Mesoporous silica nanoparticles (MSNs) find tremendous applications in
drug delivery due to several advantages such as their easy fabrication
process, high drug loading, biodegradability, biocompatibility, and so
forth. Nevertheless, despite several advantages, the use of this
striking drug delivery carrier is restricted due to premature drug
release owing to the porous structure. Coating of the pores using
polymers has emerged as a great solution to this problem. Polymer
coatings, which act as gatekeepers, avoid the premature release of
loaded content from MSNs and offers the opportunity for controlled and
targeted drug delivery. Therefore, in this review, we have compiled the
polymer-based coating approaches used in recent years for improving the
drug delivery capability of MSNs. This manuscript provides an insight
into the research about the potential of polymer-coated MSNs, allowing
the selection of right polymer for coating purposes according to the
desired application.


Keywords

controlled drug delivery, Customized drug delivery device, drug delivery, drug-delivery systems, Drug delivery systems, mesoporous materials, Mesoporous silica, Micro-Mesoporous material, polymer


Documents


Last updated on 2020-19-09 at 05:16