Facile methodology of nanoemulsion preparation using oily polymer for the delivery of poorly soluble drugs

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Wik J, Bansal KK, Assmuth T, Rosling A, Rosenholm JM
Publisher: Springer US
Publication year: 2019
Journal: Drug Delivery and Translational Research
ISSN: 2190-3948


Abstract

Aqueous solubility of an active pharmaceutical ingredient (API) is a
determining factor that has a direct impact on formulation strategies
and overall bioavailability. Fabrication of nanoemulsions of poorly
soluble drugs is one of the widely utilized approaches to overcome this
problem. However, thermodynamic instability and tedious manufacturing
processes of nanoemulsions limit their clinical translation. Therefore,
this study was focused on circumventing the abovementioned hurdles by
utilizing the polymer as an oil phase, instead of conventional oils. The
nanoemulsion was prepared via a facile low-energy nanoprecipitation
method using renewable poly(δ-decalactone) (PDL), as an oil phase and
Pluronic F-68 as surfactant. The prepared nanoemulsions were
characterized in terms of size, drug encapsulation efficiency,
stability, and toxicity. Five different hydrophobic drugs were utilized
to evaluate the drug delivery capability of the PDL nanoemulsion. The
prepared nanoemulsions with sizes less than 200 nm were capable to
enhance the aqueous solubility of the drugs by 3 to 10 times compared
with the well-established Pluronic F-68 micelles. No phase separation or
significant changes in size and drug content was observed with PDL
nanoemulsions after high-speed centrifugation and 3 months of storage at
two different temperatures (20 °C and 50 °C). PDL nanoemulsions were
found to be non-heamolytic up to concentrations of 1 mg/mL, and the cell
cytotoxicity studies on MDA-MB-231 and MEF cells suggest a
concentration and time-dependent toxicity, where the PDL polymer itself
induced no cytotoxicity. The results from this study clearly indicate
that the PDL polymer has a tremendous potential to be utilized as an oil
phase to prepare stable nanoemulsions via a facile methodology,
ultimately favouring clinical translations.


Keywords

Emulsion, Emulsions, Emulsion stability, polymer, Poorly soluble drug, Poorly soluble drugs, Poorly water-soluble drugs


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Last updated on 2020-28-05 at 03:03