Biodistribution, Excretion, and Toxicity of Inorganic Nanoparticles

B2 Book section


Internal Authors/Editors


Publication Details

List of Authors: Casals E, Casals G, Puntes V, Rosenholm JM
Editors: Wenguo Cui, Xin Zhao
Publisher: Elsevier
Publication year: 2019
Publisher: Elsevier
Book title: Theranostic Bionanomaterials
Title of series: Micro and Nano Technologies
Start page: 3
End page: 26
ISBN: 978-0-12-815341-3


Abstract

The aim of this chapter is to provide a summary of the current knowledge
of the full life cycle of inorganic nanoparticles (NPs) in
physiological environments related to medical applications. The response
of NPs inside organisms or released into the environment is complex and
diverse, and a variety of parameters are involved: NPs may be
aggregated into microscopic particles or embedded in exposed materials;
their surfaces, which determine their bioactivity, experience constant
modifications; NPs may corrode and dissolve; or they can suffer
morphological modifications. Thus in physiological environments and
inside the body, the effects, biodistribution, potential toxicity, and
fate of NPs depend not only on their composition and designed
morphological and surface properties, but mainly on the modifications
they undergo depending on the exposure media. All this is reviewed and
discussed in this chapter.


Keywords

aggregation, dissolution, Nanomedicine, Nanoparticle, nanoparticles, Toxicology

Last updated on 2020-04-06 at 03:05