Fast and efficient copper-mediated 18F-fluorination of arylstannanes, aryl boronic acids, and aryl boronic esters without azeotropic drying

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Salla Orvokki Lahdenpohja, Noora Annika Rajala, Johan Rajander, Anna Kaarina Kirjavainen
Publisher: Springer International Publishing
Publication year: 2019
Journal: EJNMMI Radiopharmacy and Chemistry
Volume number: 4
eISSN: 2365-421X


Copper-mediated radiofluorination is a straightforward method to produce a variety of [18F]fluoroarenes and [18F]fluoroheteroarenes. To minimize the number of steps in the production of 18F-labelled radiopharmaceuticals, we have developed a short and efficient azeotropic drying-free 18F-labelling method using copper-mediated fluorination. Our goal was to improve the copper-mediated method to achieve wide substrate scope with good radiochemical yields with short synthesis time.

Last updated on 2020-26-05 at 04:40