Fast and efficient copper-mediated 18F-fluorination of arylstannanes, aryl boronic acids, and aryl boronic esters without azeotropic drying

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


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Publikationens författare: Salla Orvokki Lahdenpohja, Noora Annika Rajala, Johan Rajander, Anna Kaarina Kirjavainen
Förläggare: Springer International Publishing
Publiceringsår: 2019
Tidskrift: EJNMMI Radiopharmacy and Chemistry
Volym: 4
eISSN: 2365-421X


Abstrakt

Copper-mediated radiofluorination is a straightforward method to produce a variety of [18F]fluoroarenes and [18F]fluoroheteroarenes. To minimize the number of steps in the production of 18F-labelled radiopharmaceuticals, we have developed a short and efficient azeotropic drying-free 18F-labelling method using copper-mediated fluorination. Our goal was to improve the copper-mediated method to achieve wide substrate scope with good radiochemical yields with short synthesis time.


Senast uppdaterad 2020-26-05 vid 04:40

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