Rapid spread of mannan to the immune system, skin and joints within 6 hours after local exposure

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: C Hagert, R Siitonen, X-G Li, H Liljenbäck, A Roivainen, R Holmdahl
Publisher: Wiley
Publication year: 2019
Journal: Clinical and Experimental Immunology
Volume number: 196
Issue number: 3
Start page: 383
End page: 391


Abstract

Psoriasis (Ps), psoriatic arthritis (PsA) and rheumatoid arthritis (RA)
are common diseases dependent on environmental factors that activate the
immune system in unknown ways. Mannan is a group of polysaccharides
common in the environment; they are potentially pathogenic, because at
least some of them induce Ps‐, PsA‐ and RA‐like inflammation in mice.
Here, we used positron emission tomography/computed tomography to
examine in‐vivo transport and spread of mannan labelled with fluorine‐18 [18F].
The results showed that mannan was transported to joints (knee) and
bone marrow (tibia) of mice within 6 h after intraperitoneal injection.
The time it took to transport mannan, and its presence in blood,
indicated cellular transport of mannan within the circulatory system. In
addition, mannan was filtered mainly through the spleen and liver. [18F]fluoromannan
was excreted via kidneys, small intestine and, to some extent, the
mouth. In conclusion, mannan reaches joints rapidly after injection,
which may explain why mannan‐induced inflammatory disease is targeted to
these tissues.


Last updated on 2020-12-08 at 05:36