The cytoskeleton of digestive epithelia in health and disease

A2 Review article, Literature review, Systematic review


Internal Authors/Editors


Publication Details

List of Authors: Ku NO, Zhou XJ, Toivola DM, Omary MB
Publisher: AMER PHYSIOLOGICAL SOC
Publication year: 1999
Journal: AJP - Gastrointestinal and Liver Physiology
Journal acronym: AM J PHYSIOL-GASTR L
Volume number: 277
Issue number: 6
Start page: G1108
End page: G1137
Number of pages: 30
ISSN: 0193-1857


Abstract

The mammalian cell cytoskeleton consists of a diverse group of fibrillar elements that play a pivotal role in mediating a number of digestive and nondigestive cell functions, including secretion, absorption, motility, mechanical integrity, and mitosis. The cytoskeleton of higher-eukaryotic cells consists of three highly abundant major protein families: microfilaments (MF), microtubules (MT), and intermediate filaments (IF), as well as a growing number of associated proteins. Within digestive epithelia, the prototype members of these three protein families are actins, tubulins, and keratins, respectively. This review highlights the important structural, regulatory, functional, and unique features of the three major cytoskeletal protein groups in digestive epithelia. The emerging exciting biological aspects of these protein groups are their involvement in cell signaling via direct or indirect interaction with a growing list of associated proteins (MF, MT, IF), the identification of several disease-causing mutations (IF, MF), the functional role that they play in protection from environmental stresses (IF), and their functional integration via several linker proteins that bridge two or potentially ail three of these groups together. The use of agents that target specific cytoskeletal elements as therapeutic modalities for digestive diseases offers potential unique areas of intervention that remain to be fully explored.


Keywords

intermediate filaments, keratins, microfilaments, microtubules, tubulin

Last updated on 2019-22-07 at 05:56