Intermediate filaments take the heat as stress proteins

A2 Review article, Literature review, Systematic review

Internal Authors/Editors

Publication Details

List of Authors: Toivola DM, Strnad P, Habtezion A, Omary MB
Publication year: 2010
Journal: Trends in Cell Biology
Journal acronym: TRENDS CELL BIOL
Volume number: 20
Issue number: 2
Start page: 79
End page: 91
Number of pages: 13
ISSN: 0962-8924


Intermediate filament (IF) proteins and heat shock proteins (HSPs) are large multimember families that share several features, including protein abundance, significant upregulation in response to a variety of stresses, cytoprotective functions, and the phenocopying of several human diseases after IF protein or HSP mutation. We are now coming to understand that these common elements point to IFs as important cellular stress proteins with some roles akin to those already well-characterized for HSPs. Unique functional roles for IFs include protection from mechanical stress, whereas HSPs are characteristically involved in protein folding and as chaperones. Shared IF and HSP cytoprotective roles include inhibition of apoptosis, organelle homeostasis, and scaffolding. In this report, we review data that corroborate the view that IFs function as highly specialized cytoskeletal stress proteins that promote cellular organization and homeostasis.

Last updated on 2020-27-01 at 04:29