Cellular integrity plus: organelle-related and protein-targeting functions of intermediate filaments

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Toivola DM, Tao GZ, Habtezion A, Liao J, Omary MB
Publisher: ELSEVIER SCIENCE LONDON
Publication year: 2005
Journal: Trends in Cell Biology
Journal acronym: TRENDS CELL BIOL
Volume number: 15
Issue number: 11
Start page: 608
End page: 617
Number of pages: 10
ISSN: 0962-8924


Abstract

Intermediate filament proteins (IFs) maintain cell and tissue integrity, based on evidence of their polymerization and mechanical properties, abundance and disease-associated phenotypes. This 'traditional' function is now augmented by organelle-related and protein-targeting roles. Mitochondrial location and function depend on intact IFs, as demonstrated for desmin, keratins and neurofilaments. Golgi positioning is regulated by several IFs, and endosomal/lysosomal protein distribution by vimentin. IFs dramatically affect nuclear function and shape and play a role in subcellular and membrane targeting of proteins. These functions have been noted in tissues but in some cases only in cell culture. The IF-related organelle-specific and protein-targeting roles, which are likely interrelated, provide functions beyond cell scaffolding and integrity and contribute to the cytoprotective and tissue-specific functions of IF proteins.

Last updated on 2019-17-10 at 01:45