ANOMALOUS DOSE-RESPONSE RELATIONSHIP DUE TO ASSOCIATION COLLOIDAL BEHAVIOUR OF SOLUBLE AMPHIPHILIC COMPOUNDS

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: ISOMAA B, HÄGERSTRAND H, TOIVOLA D
Förläggare: FRAME
Publiceringsår: 1991
Tidskrift: Alternatives to Laboratory Animals
Tidskriftsakronym: ATLA-ALTERN LAB ANIM
Volym: 19
Artikelns första sida, sidnummer: 194
Artikelns sista sida, sidnummer: 198
Antal sidor: 5
ISSN: 0261-1929


Abstrakt

Water-soluble amphiphiles may, above a certain concentration, form colloidal aggregates (micelles or liquid crystals). If such aggregates are formed, there may be a competition between the micelles or the liquid crystals and the biological target for the monomeric form of the amphiphile. This may reduce the number of monomers available for the biological target, which in turn may be reflected in concentration-dependent processes. Therefore, caution should be taken when examining dose-response with soluble amphiphiles forming micelles at low concentrations.


Nyckelord

AMPHIPHILE, CRITICAL MICELLE CONCENTRATION, DOSE-RESPONSE, erythrocyte membrane, hemolysis

Senast uppdaterad 2019-13-12 vid 03:23