ANOMALOUS DOSE-RESPONSE RELATIONSHIP DUE TO ASSOCIATION COLLOIDAL BEHAVIOUR OF SOLUBLE AMPHIPHILIC COMPOUNDS

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: ISOMAA B, HÄGERSTRAND H, TOIVOLA D
Publisher: FRAME
Publication year: 1991
Journal: Alternatives to Laboratory Animals
Journal acronym: ATLA-ALTERN LAB ANIM
Volume number: 19
Start page: 194
End page: 198
Number of pages: 5
ISSN: 0261-1929


Abstract

Water-soluble amphiphiles may, above a certain concentration, form colloidal aggregates (micelles or liquid crystals). If such aggregates are formed, there may be a competition between the micelles or the liquid crystals and the biological target for the monomeric form of the amphiphile. This may reduce the number of monomers available for the biological target, which in turn may be reflected in concentration-dependent processes. Therefore, caution should be taken when examining dose-response with soluble amphiphiles forming micelles at low concentrations.


Keywords

AMPHIPHILE, CRITICAL MICELLE CONCENTRATION, DOSE-RESPONSE, erythrocyte membrane, hemolysis

Last updated on 2019-17-06 at 05:04