'Heads and tails' of intermediate filament phosphorylation: multiple sites and functional insights

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Omary MB, Ku NO, Tao GZ, Toivola DM, Liao J
Förläggare: ELSEVIER SCIENCE LONDON
Publiceringsår: 2006
Tidskrift: Trends in Biochemical Sciences
Tidskriftsakronym: TRENDS BIOCHEM SCI
Volym: 31
Nummer: 7
Artikelns första sida, sidnummer: 383
Artikelns sista sida, sidnummer: 394
Antal sidor: 12
ISSN: 0968-0004


Abstrakt

Intermediate filaments (IFs) are major components of the mammalian cytoskeleton. They are among the most abundant cellular phosphoproteins; their phosphorylation typically involves multiple sites at repeat or unique motifs, preferentially within the 'head' or 'tail' domains. Phosphorylation and dephosphorylation are essential for the regulation of IF dynamics by modulating the intrinsic properties of IFs: solubility, conformation and filament organization, and, in addition, for the regulation of other IF post-translational modifications. These phosphorylation-regulated properties dictate generalized and context-dependent IF functions that reflect their tissue-specific expression. Most important among IF phosphorylation-mediated functions are the regulation of IF cellular or subcellular compartmentalization, levels and turnover, binding with associated proteins, susceptibility to cell stresses (including apoptosis), tissue-specific functions and IF-associated disease pathogenesis (where IF hyperphosphorylation also serves as a tissue-injury marker).

Senast uppdaterad 2019-15-12 vid 03:45