'Heads and tails' of intermediate filament phosphorylation: multiple sites and functional insights

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Omary MB, Ku NO, Tao GZ, Toivola DM, Liao J
Publisher: ELSEVIER SCIENCE LONDON
Publication year: 2006
Journal: Trends in Biochemical Sciences
Journal acronym: TRENDS BIOCHEM SCI
Volume number: 31
Issue number: 7
Start page: 383
End page: 394
Number of pages: 12
ISSN: 0968-0004


Abstract

Intermediate filaments (IFs) are major components of the mammalian cytoskeleton. They are among the most abundant cellular phosphoproteins; their phosphorylation typically involves multiple sites at repeat or unique motifs, preferentially within the 'head' or 'tail' domains. Phosphorylation and dephosphorylation are essential for the regulation of IF dynamics by modulating the intrinsic properties of IFs: solubility, conformation and filament organization, and, in addition, for the regulation of other IF post-translational modifications. These phosphorylation-regulated properties dictate generalized and context-dependent IF functions that reflect their tissue-specific expression. Most important among IF phosphorylation-mediated functions are the regulation of IF cellular or subcellular compartmentalization, levels and turnover, binding with associated proteins, susceptibility to cell stresses (including apoptosis), tissue-specific functions and IF-associated disease pathogenesis (where IF hyperphosphorylation also serves as a tissue-injury marker).

Last updated on 2019-19-07 at 07:09