Self-Assembly of Enzyme-Like Nanofibrous G-Molecular Hydrogel for Printed Flexible Electrochemical Sensors

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)

Interna författare/redaktörer

Publikationens författare: Zhong RB, Tang Q, Wang SP, Zhang HB, Zhang F, Xiao MS, Man TT, Qu XM, Li L, Zhang WJ, Pei H
Publiceringsår: 2018
Tidskrift: Advanced Materials
Tidskriftsakronym: ADV MATER
Volym: 30
Nummer: 12
Antal sidor: 8
ISSN: 0935-9648


Conducting hydrogels provide great potential for creating designer shape-morphing architectures for biomedical applications owing to their unique solid-liquid interface and ease of processability. Here, a novel nanofibrous hydrogel with significant enzyme-like activity that can be used as ink to print flexible electrochemical devices is developed. The nanofibrous hydrogel is self-assembled from guanosine (G) and KB(OH)(4) with simultaneous incorporation of hemin into the G-quartet scaffold, giving rise to significant enzyme-like activity. The rapid switching between the sol and gel states responsive to shear stress enables free-form fabrication of different patterns. Furthermore, the replication of the G-quartet wires into a conductive matrix by in situ catalytic deposition of polyaniline on nanofibers is demonstrated, which can be directly printed into a flexible electrochemical electrode. By loading glucose oxidase into this novel hydrogel, a flexible glucose biosensor is developed. This study sheds new light on developing artificial enzymes with new functionalities and on fabrication of flexible bioelectronics.


enzyme mimicking, flexible electrochemical sensors, guanosine, low-molecular-weight hydrogels, self-assembly


Senast uppdaterad 2020-28-02 vid 05:04