Handheld colorimeter as quality control tool for inkjet printed flexible levothyroxine doses for pediatric use

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Henrika Wickström, Anouk Broos, Johan O Nyman, Ewelina Kortesmäki, Patrik Eklund, Thomas de Beer, Maren Preis, Niklas Sandler
Redaktörer: Smita Salunke, Catherine Tuleu
Publiceringsår: 2018
Tidskrift: International Journal of Pharmaceutics
Förläggare: Elsevier
Moderpublikationens namn: Formulating Better Medicines for Children – European Paediatric Formulation Initiative (EuPFI) 2016
Tidskriftsakronym: Int. J. Pharm.
Nummer i serien: 2
Volym: 536
Nummer: 2
Artikelns första sida, sidnummer: 508
Artikelns sista sida, sidnummer: 509
eISSN: 1873-3476


Abstrakt

There is a need to formulate and develop age- and weight-appropriate oral dosage forms for pediatric use. The aim of this work was to manufacture flexible doses of levothyroxine (T4) on an edible bilayered substrate using inkjet technology. The use of a handheld colorimeter as a quality control tool, to differentiate between doses with different color intensities, was also studied. The need for orally dissolvable T4 formulations was addressed in the Best Pharmaceuticals for Children Act (BPCA) Priority List of Needs in Pediatric Therapeutics of the National Health Institution of the United States (BPCA, 2012).


Senast uppdaterad 2019-07-12 vid 03:15

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