Oxyethylene chain-cation complexation; Nonionic polyoxyethylene detergents attain a positive charge and demonstrate electrostatic head group interactions

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Hagerstrand H, Bobacka J, Bobrowska-Hagerstrand M, Kralj-Iglic V, Fosnaric M, Iglic A
Förläggare: CELLULAR & MOLECULAR BIOLOGY LETTERS
Publiceringsår: 2001
Tidskrift: Cellular and Molecular Biology Letters
Tidskriftsakronym: CELL MOL BIOL LETT
Volym: 6
Artikelns första sida, sidnummer: 161
Artikelns sista sida, sidnummer: 165
Antal sidor: 5
ISSN: 1425-8153


Abstrakt

We report literature data indicating that the polyoxyethylene chain of polyoxyethylene detergents attracts cations via dipole-ion interactions thereby attaining a positive charge character. This implies that nonionic polyoxyethylene detergents like Triton X-100 and C12E8 may interact electrostatically with phospholipid head groups. We describe how a positive charge character of Triton X-100 and C12E8 can explain their hitherto mysterious stomatocytogenic shape altering effect in human erythrocytes.


Nyckelord

CmEn, erythrocyte membrane, PEG, polyoxyethylene, shape change, Triton X-100

Senast uppdaterad 2020-02-04 vid 04:25