Core-Shell Structures of Upconversion Nanocrystals Coated with Silica for Near Infrared Light Enabled Optical Imaging of Cancer Cells

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Lingeshwar Reddy K, Prabhakar N, Rosenholm JM, Krishnan V
Publisher: MDPI
Publication year: 2018
Journal: Micromachines
Volume number: 9
Issue number: 8
ISSN: 2072-666X


Abstract

Optical imaging of cancer cells using near infrared (NIR) light is currently an active area of research, as this spectral region directly corresponds to the therapeutic window of biological tissues. Upconversion nanocrystals are photostable alternatives to conventional fluorophores. In our work, we have prepared upconversion nanocrystals of NaYF4:Yb/Er and encapsulated them in silica to form core-shell structures. The as-prepared core-shell nanostructures have been characterized for their structure, morphology, and optical properties using X-ray diffraction, transmission electron microscopy coupled with elemental mapping, and upconversion luminescence spectroscopy, respectively. The cytotoxicity examined using cell viability assay indicated a low level of toxicity of these core-shell nanostructures. Finally, these core-shell nanostructures have been utilized as photostable probes for NIR light enabled optical imaging of human breast cancer cells. This work paves the way for the development of advanced photostable, biocompatible, low-toxic core-shell nanostructures for potential optical imaging of biological cells and tissues.


Keywords

bioimaging, Core-shell, NIR, Upconverting nanophosphors


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Last updated on 2019-14-12 at 03:25