3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Chunlin Xu, Binbin Zhang Molino, Xiaoju Wang, Fang Cheng, Wenyang Xu, Paul Molino, Markus Bacher, Dandan Su, Thomas Rosenau, Stefan Willför, Gordon Wallace
Publisher: RSC
Publication year: 2018
Journal: Journal of Materials Chemistry. B
Journal acronym: J. Mater. Chem. B,
Volume number: 6
Issue number: 43
Start page: 7066
End page: 7075
Number of pages: 10
ISSN: 2050-750X
eISSN: 2050-7518


We present for the first time approaches to 3D-printing of nanocellulose hydrogel scaffolds based on double crosslinking, first by in situ Ca2+ crosslinking and post-printing by chemical crosslinking with 1,4-butanediol diglycidyl ether (BDDE). Scaffolds were successfully printed from 1% nanocellulose hydrogels, with their mechanical strength being tunable in the range of 3 to 8 kPa. Cell tests suggest that the 3D-printed and BDDE-crosslinked nanocellulose hydrogel scaffolds supported fibroblast cells' proliferation, which was improving with increasing rigidity. These 3D-printed scaffolds render nanocellulose a new member of the family of promising support structures for crucial cellular processes during wound healing, regeneration and tissue repair.


Last updated on 2020-12-07 at 06:05