Mesoporous silica nanoparticles as diagnostic and therapeutic tools: how can they combat bacterial infection?

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Şen Karaman D, Manner S, Rosenholm JM
Förläggare: Future Science Ltd London, UK
Publiceringsår: 2018
Tidskrift: Therapeutic Delivery
Volym: 9
Nummer: 4
Artikelns första sida, sidnummer: 241
Artikelns sista sida, sidnummer: 244
ISSN: 2041-5990


Abstrakt

Nanoparticle-based
drug delivery is one of the most promising approaches to overcome the
challenges in the delivery of therapeutic compounds to the site of
interest. The size of particles on the nanoscale provides them access to
many otherwise inaccessible areas in the body. With the aid of
nanoparticle-based drug-delivery systems, the drug of interest can be
accumulated at the necessary site whereby the penetration of the drug
through the target cells is improved. The essential aim of drug delivery
is not only to improve efficacy, safety and/or patient comfort but also
the personalization of therapies tailoring the design of the
drug-delivery systems. With the sophisticated design of nanoparticles,
prominent therapeutic and diagnostic functionalities can be obtained
that are quite distinctive from those obtainable by conventional
approaches.

An
increasing number of bacterial infections are caused by
antibiotic-resistant strains and persistent biofilms, which are
structured communities of bacterial cells embedded in a self-produced
matrix, and attributed to a variety of chronic infections [1].
Implementation of nanoparticle-based antibacterial treatments and
diagnosis is currently considered one of the most promising strategies
to overcome the challenges of bacterial infections, such as the
increasing treatment failures caused by antimicrobial resistance and the
persistent nature of biofilms in the treatments; as well as the
declined investments in antimicrobial drug discovery during the past few
decades [2].
The groundbreaking approaches in combating bacterial infections has
been devoted to the utilization of nanoparticles as versatile tools for
the diagnosis as well as prevention (e.g., vaccination and medical
devices) and treatment of bacterial infections [3].


Nyckelord

Anti-biofilm, Bacterial biofilms, biofilms, infections, mesoporous silica nanoparticles, Nanoantibiotics


Dokument


Senast uppdaterad 2019-19-07 vid 04:32