Birth mode is associated with earliest strain-conferred gut microbiome functions and immunostimulatory potential

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Linda Wampach, Anna Heintz-Buschart, Joelle V. Fritz, Javier Ramiro-Garcia, Janine Habier, Malte Herold, Shaman Narayanasamy, Anne Kaysen, Angela H. Hogan, Lutz Bindl, Jean Bottu, Rashi Halder, Conny Sjöqvist, Patrick May, Anders F. Andersson, Carine de Beaufort, Paul Wilmes
Publisher: Nature Publishing Group
Publication year: 2018
Journal: Nature Communications
Journal acronym: Nat Commun
Volume number: 9


Abstract

The rate of caesarean section delivery (CSD) is increasing worldwide. It remains unclear
whether disruption of mother-to-neonate transmission of microbiota through CSD occurs and
whether it affects human physiology. Here we perform metagenomic analysis of earliest gut
microbial community structures and functions. We identify differences in encoded functions
between microbiomes of vaginally delivered (VD) and CSD neonates. Several functional
pathways are over-represented in VD neonates, including lipopolysaccharide (LPS) biosynthesis.
We link these enriched functions to individual-specific strains, which are transmitted
from mothers to neonates in case of VD. The stimulation of primary human immune
cells with LPS isolated from early stool samples of VD neonates results in higher levels of
tumour necrosis factor (TNF-α) and interleukin 18 (IL-18). Accordingly, the observed levels
of TNF-α and IL-18 in neonatal blood plasma are higher after VD. Taken together, our results
support that CSD disrupts mother-to-neonate transmission of specific microbial strains,
linked functional repertoires and immune-stimulatory potential during a critical window for
neonatal immune system priming.


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Last updated on 2019-06-12 at 03:09