JNK Regulation of Depression and Anxiety.

A2 Granskningsartikel, litteraturgranskning, systematisk granskning


Interna författare/redaktörer


Publikationens författare: Patrik Hollos, Francesca Marchisella, Eleanor T. Coffey
Publiceringsår: 2018
Tidskrift: Brain Plasticity
Tidskriftsakronym: Brain Plast
Volym: 3
Nummer: 2
Artikelns första sida, sidnummer: 145
Artikelns sista sida, sidnummer: 155
ISSN: 2213-6312


Abstrakt

Depression and anxiety are the most common mood disorders affecting 300 million sufferers worldwide. Maladaptive changes in the neuroendocrine stress response is cited as the most common underlying cause, though how the circuits underlying this response are controlled at the molecular level, remains largely unknown. Approximately 40% of patients do not respond to current treatments, indicating that untapped mechanisms exist. Here we review recent evidence implicating JNK in the control of anxiety and depressive-like behavior with a particular focus on its action in immature granule cells of the hippocampal neurogenic niche and the potential for therapeutic targeting for affective disorders.

Senast uppdaterad 2019-20-07 vid 07:02