Novel functions of vimentin in cell adhesion, migration, and signaling

A2 Review article, Literature review, Systematic review


Internal Authors/Editors


Publication Details

List of Authors: Ivaska, Pallari, Nevo, Eriksson
Publication year: 2007
Journal: Experimental Cell Research
Journal acronym: Exp Cell Res
Volume number: 313
Issue number: 10
Start page: 2050
End page: 2062
ISSN: 0014-4827
eISSN: 1090-2422


Abstract

Vimentin is the major intermediate filament (IF) protein of mesenchymal cells. It shows dynamically altered expression patterns during different developmental stages and high sequence homology throughout all vertebrates, suggesting that the protein is physiologically important. Still, until recently, the real tasks of vimentin have been elusive, primarily because the vimentin-deficient mice were originally characterized as having a very mild phenotype. Recent studies have revealed several key functions for vimentin that were not obvious at first sight. Vimentin emerges as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. The highly dynamic and complex phosphorylation of vimentin seems to be a likely regulator mechanism for these functions. The implicated novel vimentin functions have broad ramifications into many different aspects of cell physiology, cellular interactions, and organ homeostasis.

Last updated on 2019-07-12 at 03:32