Cell selective cytotoxicity of a peptide toxin from the cyanobacterium Microcystis aeruginosa

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Eriksson, Hägerstrand, Isomaa
Publication year: 1987
Journal: BBA - Biochimica et Biophysica Acta
Journal acronym: Biochim Biophys Acta
Volume number: 930
Issue number: 3
Start page: 304
End page: 310
ISSN: 0006-3002


Abstract

The effects of a cyclic peptide toxin, isolated from the cyanobacterium Microcystis aeruginosa, on cell morphology and ion transport in human erythrocytes, isolated rat hepatocytes and mouse fibroblasts (3T3) were studied. Neither in erythrocytes nor in fibroblasts did the toxin cause morphological alterations. In hepatocytes the toxin induced marked morphological alterations at a concentration of about 50 nM. In erythrocytes and fibroblasts no effects on ion transport were observed. In hepatocytes the toxin induced a significant increase in both phosphate and potassium efflux at concentrations far below the concentration causing morphological alterations (0.1 and 1 nM, respectively). It is suggested that the cytotoxicity of the toxin is not due to a non-specific interaction with the plasma membrane and that the effects of the toxin in hepatocytes are probably due to an interaction of the toxin with cytoskeletal elements.

Last updated on 2019-22-08 at 05:07