Correlated genetic and non-shared environmental influences account for the co-morbidity between female sexual dysfunctions

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)

Interna författare/redaktörer

Publikationens författare: Witting K, Santtila P, Rijsdijk F, Varjonen M, Jern P, Johansson A, von der Pahlen B, Alanko K, Sandnabba NK
Publiceringsår: 2009
Tidskrift: Psychological Medicine
Tidskriftsakronym: Psychol Med
Volym: 39
Nummer: 1
Artikelns första sida, sidnummer: 115
Artikelns sista sida, sidnummer: 127
ISSN: 0033-2917


BACKGROUND Previous studies have shown moderate heritability for female orgasm. So far, however, no study has addressed the pattern of genetic and environmental influences on diverse sexual dysfunctions in women, nor how genetic and environmental factors contribute to the associations between them.
METHOD The sample was drawn from the Genetics of Sex and Aggression (GSA) sample and consisted of 6, 446 female twins (aged 18-43 years) and 1994 female siblings (aged 18-49 years). The participants responded to the Female Sexual Function Index (FSFI), either by post or online.
RESULTS Model fitting analyses indicated that individual differences on all six subdomains of the FSFI (desire, arousal, lubrication, orgasm, satisfaction, and pain) were primarily due to non-shared (individual-specific) environmental influences. Genetic influences were modest but significant, whereas shared environmental influences were not significant. A correlated factors model including additive and non-additive genetic and non-shared environmental effects proved to have the best fit and suggested that both correlated additive and non-additive genetic factors and unique environmental factors underlie the co-occurrence of the sexual function problems.
CONCLUSIONS The findings suggest that female sexual dysfunctions are separate entities with some shared aetiology. They also indicate that there is a genetic susceptibility for sexual dysfunctions. The unique experiences of each individual are, however, the main factors determining if, and which, dysfunction develops.

Senast uppdaterad 2019-21-10 vid 03:21