Intermediate filaments as signaling platforms

A2 Review article, Literature review, Systematic review

Internal Authors/Editors

Publication Details

List of Authors: Pallari, Eriksson
Publication year: 2006
Journal: Science's STKE : signal transduction knowledge environment
Journal acronym: Sci STKE
Issue number: 366
ISSN: 1525-8882


Intermediate filaments (IFs) are cytoskeletal structures that are crucial for maintaining the structural and mechanical integrity of cells and tissues. Intriguingly, a wide range of previously unknown nonmechanical roles for the IF cytoskeleton are emerging: Recent studies have linked IFs to the integration of signals related to the determination of cell size, the regulation of cell migration and cell survival, and the buffering of the effects of stress-activated kinases. The characteristic structural features and expression patterns of the different members of this diverse family of highly abundant proteins make them well suited to act as cell- and tissue-specific modifiers and organizers of signaling.

Last updated on 2020-15-08 at 05:50