Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Eriksson, Meriluoto, Kujari, Österlund, Fagerlund, Hällbom
Publication year: 1988
Journal: Toxicon
Journal acronym: Toxicon
Volume number: 26
Issue number: 2
Start page: 161
End page: 166
ISSN: 0041-0101
eISSN: 1879-3150


Abstract

A peptide toxin was isolated from the cyanobacterium Nodularia spumigena by high performance liquid chromatography (HPLC). The i.p. LD50 of the toxin was 50 micrograms/kg mouse with death within 1-3 hr. The major effects of the toxin were seen in the liver in the form of extensive haemorrhages. Amino acid analysis showed the presence of equimolar amounts of glutamic acid, beta-methyl-aspartic acid, and arginine. The toxicological and some of the chemical properties of the isolated toxin were similar to those reported for hepatotoxins isolated from the cyanobacterium Microcystis aeruginosa.

Last updated on 2019-25-08 at 05:26