Providing cellular signposts--post-translational modifications of intermediate filaments

A2 Granskningsartikel, litteraturgranskning, systematisk granskning

Interna författare/redaktörer

Publikationens författare: Hyder, Pallari, Kochin, Eriksson
Publiceringsår: 2008
Tidskrift: FEBS Letters
Tidskriftsakronym: FEBS Lett
Volym: 582
Nummer: 14
Artikelns första sida, sidnummer: 2140
Artikelns sista sida, sidnummer: 2148
ISSN: 0014-5793
eISSN: 1873-3468


Intermediate filaments are dynamically regulated by their post-translational modifications. Initially these modifications were found to regulate filament dynamics and organization. In the last few years, their roles have extended significantly to facilitating, for example, the recruitment and sequestration of signaling molecules that regulate a wide range of cellular functions. While phosphorylation has been established as the principal post-translational modification regulating intermediate filament function, other modifications with co-operative roles are emerging, adding a further dimensions to intermediate filament-mediated signaling.

Senast uppdaterad 2020-02-04 vid 09:08