Providing cellular signposts--post-translational modifications of intermediate filaments

A2 Review article, Literature review, Systematic review

Internal Authors/Editors

Publication Details

List of Authors: Hyder, Pallari, Kochin, Eriksson
Publication year: 2008
Journal: FEBS Letters
Journal acronym: FEBS Lett
Volume number: 582
Issue number: 14
Start page: 2140
End page: 2148
ISSN: 0014-5793
eISSN: 1873-3468


Intermediate filaments are dynamically regulated by their post-translational modifications. Initially these modifications were found to regulate filament dynamics and organization. In the last few years, their roles have extended significantly to facilitating, for example, the recruitment and sequestration of signaling molecules that regulate a wide range of cellular functions. While phosphorylation has been established as the principal post-translational modification regulating intermediate filament function, other modifications with co-operative roles are emerging, adding a further dimensions to intermediate filament-mediated signaling.

Last updated on 2020-30-09 at 03:11