Introducing intermediate filaments: from discovery to disease

A2 Review article, Literature review, Systematic review

Internal Authors/Editors

Publication Details

List of Authors: Eriksson, Dechat, Grin, Helfand, Mendez, Pallari, Goldman
Publication year: 2009
Journal: Journal of Clinical Investigation
Journal acronym: J Clin Invest
Volume number: 119
Issue number: 7
Start page: 1763
End page: 1771
ISSN: 0021-9738
eISSN: 1558-8238


It took more than 100 years before it was established that the proteins that form intermediate filaments (IFs) comprise a unified protein family, the members of which are ubiquitous in virtually all differentiated cells and present both in the cytoplasm and in the nucleus. However, during the past 2 decades, knowledge regarding the functions of these structures has been expanding rapidly. Many disease-related roles of IFs have been revealed. In some cases, the molecular mechanisms underlying these diseases reflect disturbances in the functions traditionally assigned to IFs, i.e., maintenance of structural and mechanical integrity of cells and tissues. However, many disease conditions seem to link to the nonmechanical functions of IFs, many of which have been defined only in the past few years.

Last updated on 2020-10-08 at 06:41

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