Structure of a hepatotoxic pentapeptide from the cyanobacterium Nodularia spumigena

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Sandström, Glemarec, Meriluoto, Eriksson, Chattopadhyaya
Publication year: 1990
Journal: Toxicon
Journal acronym: Toxicon
Volume number: 28
Issue number: 5
Start page: 535
End page: 540
ISSN: 0041-0101
eISSN: 1879-3150


The structure of a hepatotoxic peptide from the cyanobacterium Nodularia spumigena was determined using 1D and 2D proton nuclear magnetic resonance spectroscopy and fast atom bombardment mass spectrometry. The toxin was a cyclic pentapeptide (mol. wt 824.5) with the structure cyclo-(beta-methylisoAsp-Arg-Adda-isoGlu-N-methylde hydrobutyric acid) (Adda: 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid).

Last updated on 2020-10-07 at 05:31