Targeted intracellular delivery of hydrophobic agents using mesoporous hybrid silica nanoparticles as carrier systems

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Rosenholm, Peuhu, Eriksson, Sahlgren, Lindén
Publication year: 2009
Journal: Nano Letters
Journal acronym: Nano Lett
Volume number: 9
Issue number: 9
Start page: 3308
End page: 3311
ISSN: 1530-6984
eISSN: 1530-6992


Abstract

Targeted nanoparticle-mediated intracellular delivery is demonstrated using two hydrophobic fluorophores as model drug cargo. The presented hybrid carrier system exhibits both cancer cell-targeting ability and capacity to retain a hydrophobic agent with subsequent specific release into the endosomal compartment. Furthermore, the incorporated agent is shown to be able to escape from the endosomes into the cytoplasm, making the particles promising candidates as carriers for targeted drug delivery for cancer treatment.

Last updated on 2019-17-06 at 03:46