Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatases

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Eriksson JE, Toivola D, Meriluoto JA, Karaki H, Han YG, Hartshorne D
Publication year: 1990
Journal: Biochemical and Biophysical Research Communications
Journal acronym: Biochem Biophys Res Commun
Volume number: 173
Issue number: 3
Start page: 1347
End page: 1353
ISSN: 0006-291X


Abstract

The cyclic peptide hepatotoxins microcystin-LR, 7-desmethyl-microcystin-RR and nodularin are potent inhibitors of the protein phosphatases type 1 and type 2A. Their potency of inhibition resembles calyculin-A and to a lesser extent okadaic acid. These hepatotoxins increase the overall level of protein phosphorylation in hepatocytes. Evidence is presented to indicate that in hepatocytes the morphological changes and effects on the cytoskeleton are due to phosphatase inhibition. The potency of these compounds in inducing hepatocyte deformation is similar to their potency in inhibiting phosphatase activity. These results suggest that the hepatotoxicity of these peptides is related to inhibition of phosphatases, and further indicate the importance of the protein phosphorylation in maintenance of structural and homeostatic integrity in these cells.

Last updated on 2019-16-07 at 05:51