New nucleoside analogs from 2-amino-9-(β-D-ribofuranosyl)purine

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Virta P, Holmström T, Roslund MU, Mattjus P, Kronberg L, Sjöholm R
Publiceringsår: 2004
Tidskrift: Organic and Biomolecular Chemistry
Tidskriftsakronym: ORG BIOMOL CHEM
Volym: 2
Nummer: 6
Artikelns första sida, sidnummer: 821
Artikelns sista sida, sidnummer: 827
Antal sidor: 7
ISSN: 1477-0520
eISSN: 1477-0539


Abstrakt

Four novel derivatives of 2-amino-9-(beta-D-ribofuranosyl) purine ( 1) were synthesised and fully characterised. When 1 was reacted with chloroacetaldehyde (a), 2-chloropropanal (b), bromomalonaldehyde (c) and a mixture of chloroacetaldehyde + malonaldehyde (d), 3-(beta-D-ribofuranosyl)- imidazo-[1,2a] purine (2), 3-(beta-D-ribofuranosyl)-5- methylimidazo-[1,2a] purine (3), 3-(beta-D-ribofuranosyl)-5-formylimidazo-[1,2a] purine (4) and 9-(beta-D-ribofuranosyl)-2-( 3,5-diformyl-4-methyl-1,4-dihydro-1-pyridyl) purine (5) were formed, respectively. The products were isolated, purified by chromatography and characterised by MS, complete NMR assignment as well as fluorescence and UV spectroscopy. The yields of these reactions were moderate ( 14 - 20%). The fluorescence properties differed from those of the starting compound and the quantum yields were considerably lower.

Senast uppdaterad 2019-16-09 vid 05:18