Voxel-based analysis of cerebral glucose metabolism in mono- and dizygotic twins discordant for Alzheimer disease

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Virta JJ, Aalto S, Järvenpaa T, Karrasch M, Kaprio J, Koskenvuo M, Räihä I, Viljanen T, Rinne JO
Publication year: 2009
Journal: Journal of Neurology, Neurosurgery and Psychiatry
Journal acronym: J NEUROL NEUROSUR PS
Volume number: 80
Issue number: 3
Start page: 259
End page: 266
Number of pages: 8
ISSN: 0022-3050


Results: In the demented MZ and DZ co-twins, cerebral glucose metabolism was extensively reduced compared with controls. The non-demented MZ co-twins showed reduced metabolism in inferior frontal, lateral temporal, parietal and medial temporal cortices as well as in the thalamus, putamen and right amygdala. In contrast, no reductions were found in the non-demented DZ co-twins. The reduction found in the non-demented MZ co-twins may be an indicator of genetic susceptibility to AD.

Last updated on 2020-21-09 at 05:55