Voxel-based analysis of cerebral glucose metabolism in mono- and dizygotic twins discordant for Alzheimer disease

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Virta JJ, Aalto S, Järvenpaa T, Karrasch M, Kaprio J, Koskenvuo M, Räihä I, Viljanen T, Rinne JO
Förläggare: B M J PUBLISHING GROUP
Publiceringsår: 2009
Tidskrift: Journal of Neurology, Neurosurgery and Psychiatry
Tidskriftsakronym: J NEUROL NEUROSUR PS
Volym: 80
Nummer: 3
Artikelns första sida, sidnummer: 259
Artikelns sista sida, sidnummer: 266
Antal sidor: 8
ISSN: 0022-3050


Abstrakt

Results: In the demented MZ and DZ co-twins, cerebral glucose metabolism was extensively reduced compared with controls. The non-demented MZ co-twins showed reduced metabolism in inferior frontal, lateral temporal, parietal and medial temporal cortices as well as in the thalamus, putamen and right amygdala. In contrast, no reductions were found in the non-demented DZ co-twins. The reduction found in the non-demented MZ co-twins may be an indicator of genetic susceptibility to AD.

Senast uppdaterad 2019-13-11 vid 04:35