Rapid interferometric imaging of printed drug laden multilayer structures

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Sandler N, Kassamakov I, Ehlers H, Genina N, Ylitalo T, Haeggstrom E
Publisher: NATURE PUBLISHING GROUP
Publication year: 2014
Journal: Scientific Reports
Journal acronym: SCI REP-UK
Volume number: 4
Start page: 1
End page: 5
Number of pages: 5
ISSN: 2045-2322
eISSN: 2045-2322


Abstract

The developments in printing technologies allow fabrication of micron-size nano-layered delivery systems to personal specifications. In this study we fabricated layered polymer structures for drug-delivery into a microfluidic channel and aimed to interferometrically assure their topography and adherence to each other. We present a scanning white light interferometer (SWLI) method for quantitative assurance of the topography of the embedded structure. We determined rapidly in non-destructive manner the thickness and roughness of the structures and whether the printed layers containing polymers or/and active pharmaceutical ingredients (API) adhere to each other. This is crucial in order to have predetermined drug release profiles. We also demonstrate non-invasive measurement of a polymer structure in a microfluidic channel. It shown that traceable interferometric 3D microscopy is a viable technique for detailed structural quality assurance of layered drug-delivery systems. The approach can have impact and find use in a much broader setting within and outside life sciences.

Last updated on 2019-11-12 at 03:30