Cytotoxicities of polysubstituted chlorodicarbonyl(cyclopentadienyl) and (indenyl)ruthenium complexes

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Denys Mavrynsky, Jani Rahkila, Daniel Bandarra, Soraia Martins, Margarida Meireles, Maria José Calhorda, Ida J. Kovács, István Zupkó, Mikko M. Hänninen, Reko Leino
Förläggare: AMER CHEMICAL SOC
Publiceringsår: 2013
Tidskrift: Organometallics
Tidskriftsakronym: ORGANOMETALLICS
Volym: 32
Nummer: 10
Artikelns första sida, sidnummer: 3012
Artikelns sista sida, sidnummer: 3017
Antal sidor: 6
ISSN: 0276-7333
eISSN: 1520-6041


Abstrakt

Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (Indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1-S transiton as evidenced by flow cytometry.

Senast uppdaterad 2019-09-12 vid 02:53