Cytotoxicities of polysubstituted chlorodicarbonyl(cyclopentadienyl) and (indenyl)ruthenium complexes

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Denys Mavrynsky, Jani Rahkila, Daniel Bandarra, Soraia Martins, Margarida Meireles, Maria José Calhorda, Ida J. Kovács, István Zupkó, Mikko M. Hänninen, Reko Leino
Publisher: AMER CHEMICAL SOC
Publication year: 2013
Journal: Organometallics
Journal acronym: ORGANOMETALLICS
Volume number: 32
Issue number: 10
Start page: 3012
End page: 3017
Number of pages: 6
ISSN: 0276-7333
eISSN: 1520-6041


Abstract

Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (Indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1-S transiton as evidenced by flow cytometry.

Last updated on 2019-13-11 at 05:44