Enhanced intracellular replication of Salmonella enteritidis in HLA-B27-expressing human monocytic cells - Dependency on glutamic acid at position 45 in the B pocket of HLA-B27

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)

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Publikationens författare: Penttinen MA, Heiskanen KM, Mohapatra R, DeLay ML, Colbert RA, Sistonen L, Granfors K
Förläggare: WILEY-LISS
Publiceringsår: 2004
Tidskrift: Arthritis and Rheumatism
Tidskriftsakronym: ARTHRITIS RHEUM
Volym: 50
Nummer: 7
Artikelns första sida, sidnummer: 2255
Artikelns sista sida, sidnummer: 2263
Antal sidor: 9
ISSN: 0004-3591


Conclusion. Our data indicate that HLA-1327 expression modulates the host-microbe interaction that results in an impaired capacity of monocytes to resist intracellular replication of S enteritidis. The phenotype is dependent on glutamic acid at position 45 in the B pocket and, thus, may be due to properties of the B27 heavy chain that are related to this residue. The ability of HLA-B27 to confer susceptibility to Salmonella-triggered reactive arthritis may occur, at least in part, through these modulatory effects.

Senast uppdaterad 2019-14-10 vid 04:17