Evidence that the p38 MAP kinase pathway is dysregulated in HLA-B27-expressing human monocytic cells - Correlation with HLA-B27 misfolding

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Sahlberg AS, Penttinen MA, Heiskanen KM, Colbert RA, Sistonen L, Granfors K
Förläggare: WILEY-LISS
Publiceringsår: 2007
Tidskrift: Arthritis and Rheumatism
Tidskriftsakronym: ARTHRITIS RHEUM
Volym: 56
Nummer: 8
Artikelns första sida, sidnummer: 2652
Artikelns sista sida, sidnummer: 2662
Antal sidor: 11
ISSN: 0004-3591


Abstrakt

Conclusion. Our results show that p38 activity plays a crucial role in controlling intracellular S enteritidis in U937 cells. Enhanced replication of bacteria in B27-expressing cells requires that the HCs contain glutamic acid at position 45 and cysteine at position 67. Furthermore, in transfectants expressing misfolded B27 HCs, p38 inhibition had no significant effect on bacterial replication, suggesting that in these cells, the p38 pathway may not function properly.

Senast uppdaterad 2019-24-05 vid 03:33