Evidence that the p38 MAP kinase pathway is dysregulated in HLA-B27-expressing human monocytic cells - Correlation with HLA-B27 misfolding

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Sahlberg AS, Penttinen MA, Heiskanen KM, Colbert RA, Sistonen L, Granfors K
Publisher: WILEY-LISS
Publication year: 2007
Journal: Arthritis and Rheumatism
Journal acronym: ARTHRITIS RHEUM
Volume number: 56
Issue number: 8
Start page: 2652
End page: 2662
Number of pages: 11
ISSN: 0004-3591


Abstract

Conclusion. Our results show that p38 activity plays a crucial role in controlling intracellular S enteritidis in U937 cells. Enhanced replication of bacteria in B27-expressing cells requires that the HCs contain glutamic acid at position 45 and cysteine at position 67. Furthermore, in transfectants expressing misfolded B27 HCs, p38 inhibition had no significant effect on bacterial replication, suggesting that in these cells, the p38 pathway may not function properly.

Last updated on 2019-22-05 at 03:28