Formation of nuclear HSF1 granules varies depending on stress stimuli

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)

Interna författare/redaktörer

Publikationens författare: Holmberg CI, Illman SA, Kallio M, Mikhailov A, Sistonen L
Publiceringsår: 2000
Tidskrift: Cell Stress and Chaperones
Tidskriftsakronym: CELL STRESS CHAPERON
Volym: 5
Nummer: 3
Artikelns första sida, sidnummer: 219
Artikelns sista sida, sidnummer: 228
Antal sidor: 10
ISSN: 1355-8145


In concert with the stress-induced activation of human heat shock factor 1 (HSF1), the factor becomes inducibly phosphorylated and accumulates into nuclear granules. To date, these processes are not fully understood. Here, we show that although stress caused by the proteasome inhibitors MG132 and clasto-lactacystine beta-lactone induces the expression of Hsp70, the formation of HSF1 granules is affected differently in comparison to heat shock. Furthermore, proteasome inhibition increases serine phosphorylation on HSF1, but to a lesser extent than heat stress. Our results suggest that, depending on the type of stress stimulus, the multiple events associated with HSF1 activation might be affected differently.

Senast uppdaterad 2019-14-11 vid 02:50