Heat shock factor 1 as a coordinator of stress and developmental pathways

A3 Book section, Chapters in research books

Internal Authors/Editors

Publication Details

List of Authors: Anckar J, Sistonen L
Editors: Peter Csermely & Laszlo Vigh
Publication year: 2007
Publisher: Springer
Book title: Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks
Title of series: Advances in Experimental Medicine and Biology
Number in series: 594
Start page: 78
End page: 88
ISBN: 978-0-387-39974-4
eISBN: 978-0-387-39975-1


The transition from normal growth conditions to stressful conditions is accompanied by a robust upregulation of heat shock proteins, which dampen the cytotoxicity caused by misfolded and denatured proteins. The most prominent part of this transition occurs on the transcriptional level. In mammals, protein-damaging stress leads to the activation of heat shock factor 1(HSF1), which binds to upstream regulatory sequences in the promoters of heat shock genes. The activation of HSF1 proceeds through a multi-step pathway, involving a monomer-to-trimer transition, nuclear accumulation and extensive posttranslational modifications. In addition to its established role as the main regulator of heat shock genes, new data link HSF1 to developmental pathways. In this chapter, we examine the established stress-related functions and prospect the intriguing role of HSF1 as a developmental coordinator.

Last updated on 2020-21-09 at 05:20