HLA-B27 modulates nuclear factor kappa B activation in human monocytic cells exposed to liplopolysaccharide

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Penttinen MA, Holmberg CI, Sistonen L, Granfors K
Förläggare: WILEY-LISS
Publiceringsår: 2002
Tidskrift: Arthritis and Rheumatism
Tidskriftsakronym: ARTHRITIS RHEUM
Volym: 46
Nummer: 8
Artikelns första sida, sidnummer: 2172
Artikelns sista sida, sidnummer: 2180
Antal sidor: 9
ISSN: 0004-3591
eISSN: 1529-0131


Abstrakt

Conclusion. Our data indicate that HLA-B27 has effects on host responses to LPS that are unrelated to antigen presentation. Two crucial events in the development of arthritis, the activation of NF-kappaB and the secretion of TNFa, were found to be enhanced in HLA-B27-expressing cells upon LPS stimulation. Because LPS is known to be present in the inflamed joints of patients with reactive arthritis (ReA), the enhanced inflammatory response of HLA-B27-positive cells upon LPS stimulation offers an attractive explanation for the role of HLA-B27 in the development of ReA.

Senast uppdaterad 2019-11-12 vid 03:54