HLA-B27 modulates nuclear factor kappa B activation in human monocytic cells exposed to liplopolysaccharide

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Penttinen MA, Holmberg CI, Sistonen L, Granfors K
Publisher: WILEY-LISS
Publication year: 2002
Journal: Arthritis and Rheumatism
Journal acronym: ARTHRITIS RHEUM
Volume number: 46
Issue number: 8
Start page: 2172
End page: 2180
Number of pages: 9
ISSN: 0004-3591
eISSN: 1529-0131


Conclusion. Our data indicate that HLA-B27 has effects on host responses to LPS that are unrelated to antigen presentation. Two crucial events in the development of arthritis, the activation of NF-kappaB and the secretion of TNFa, were found to be enhanced in HLA-B27-expressing cells upon LPS stimulation. Because LPS is known to be present in the inflamed joints of patients with reactive arthritis (ReA), the enhanced inflammatory response of HLA-B27-positive cells upon LPS stimulation offers an attractive explanation for the role of HLA-B27 in the development of ReA.

Last updated on 2020-01-06 at 04:59