Multisite phosphorylation provides sophisticated regulation of transcription factors

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Holmberg CI, Tran SEF, Eriksson JE, Sistonen L
Förläggare: ELSEVIER SCIENCE LONDON
Publiceringsår: 2002
Tidskrift: Trends in Biochemical Sciences
Tidskriftsakronym: TRENDS BIOCHEM SCI
Volym: 27
Nummer: 12
Artikelns första sida, sidnummer: 619
Artikelns sista sida, sidnummer: 627
Antal sidor: 9
ISSN: 0968-0004
eISSN: 1362-4326


Abstrakt

Reversible phosphorylation is a prevalent mechanism by which the activity of eukaryotic transcription factors is regulated rapidly in response to changes in the cellular environment. Accumulated evidence has expanded the concept of phosphorylation to a process that provides dynamic and precise tuning of the transactivating potential of a factor, rather than being a static on/off switch. In the case of transcription factors such as heat shock factor 1 (HSF1), p53 and nuclear factor of activated T cells (NFAT), multisite phosphorylation enables several effects to operate within a single factor, thereby functioning as a key to signal integration. Studies on these transcription factors illustrate recent progress in solving the dynamic nature of transcriptional regulation by multisite phosphorylation.

Senast uppdaterad 2019-13-10 vid 04:35