Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease

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Interna författare/redaktörer


Publikationens författare: Anckar J, Sistonen L
Förläggare: Annual Reviews
Publiceringsår: 2011
Tidskrift: Annual Review of Biochemistry
Tidskriftsakronym: ANNU REV BIOCHEM
Volym: 80
Artikelns första sida, sidnummer: 1089
Artikelns sista sida, sidnummer: 1115
Antal sidor: 27
ISSN: 0066-4154
eISSN: 1545-4509


Abstrakt

To dampen proteotoxic stresses and maintain protein homeostasis, organisms possess a stress-responsive molecular machinery that detects and neutralizes protein damage. A prominent feature of stressed cells is the increased synthesis of heat shock proteins (Hsps) that aid in the refolding of misfolded peptides and restrain protein aggregation. Transcriptional activation of the heat shock response is orchestrated by heat shock factor 1 (HSF1), which rapidly translocates to hsp genes and induces their expression. Although the role of HSF1 in protecting cells and organisms against severe stress insults is well established, many aspects of how HSF1 senses qualitatively and quantitatively different forms of stresses have remained poorly understood. Moreover, recent discoveries that HSF1 controls life span have prompted new ways of thinking about an old transcription factor. Here, we review the established role of HSF1 in counteracting cell stress and prospect the role of HSF1 as a regulator of disease states and aging.


Nyckelord

heat shock factor, longevity, posttranslational modification, proteostasis, transcription

Senast uppdaterad 2019-12-11 vid 03:03