Roles of the heat shock transcription factors in regulation of the heat shock response and beyond

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: Pirkkala L, Nykänen P, Sistonen L
Publication year: 2001
Journal: FASEB Journal
Journal acronym: FASEB J
Volume number: 15
Issue number: 7
Start page: 1118
End page: 1131
Number of pages: 14
ISSN: 0892-6638
eISSN: 1530-6860


The heat shock response, characterized by increased expression of heat shock proteins (Hsps) is induced by exposure of cells and tissues to extreme conditions that cause acute or chronic stress. Hsps function as molecular chaperones in regulating cellular homeostasis and promoting survival. If the stress is too severe, a signal that leads to programmed cell death, apoptosis, is activated, thereby providing a finely tuned balance between survival and death, In addition to extracellular stimuli, several nonstressful conditions induce Hsps during normal cellular growth and development. The enhanced heat shock gene expression in response to various stimuli is regulated by heat shock transcription factors (HSFs), After the discovery of the family of HSFs (i.e., murine and human HSF1, 2, and 4 and a unique avian HSF3), the functional relevance of distinct HSFs is now emerging. HSF1, an HSF prototype, and HSF3 are responsible for heat-induced Hsp expression, whereas HSF2 is refractory to classical stressors, HSF4 is expressed in a tissue-specific manner; similar to HSF1 and HSF2, alternatively spliced isoforms add further complexity to its regulation. Recently developed powerful genetic models have provided evidence for both cooperative and specific functions of HSFs that expand beyond the heat shock response. Certain specialized functions of HSFs may even include regulation of novel target genes in response to distinct stimuli.


heat shock element, HSF family, hsps, knockout and transgenic HSF models

Last updated on 2020-28-09 at 03:09