Heat shock factors: integrators of cell stress, development and lifespan

A2 Granskningsartikel, litteraturgranskning, systematisk granskning


Interna författare/redaktörer


Publikationens författare: Åkerfelt M, Morimoto RI, Sistonen L
Förläggare: NATURE PUBLISHING GROUP
Publiceringsår: 2010
Tidskrift: Nature Reviews Molecular Cell Biology
Tidskriftsakronym: NAT REV MOL CELL BIO
Volym: 11
Nummer: 8
Artikelns första sida, sidnummer: 545
Artikelns sista sida, sidnummer: 555
Antal sidor: 11
ISSN: 1471-0072
eISSN: 1471-0080


Abstrakt

Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute stress. They are best known as inducible transcriptional regulators of genes encoding molecular chaperones and other stress proteins. Four members of the HSF family are also important for normal development and lifespan-enhancing pathways, and the repertoire of HSF targets has thus expanded well beyond the heat shock genes. These unexpected observations have uncovered complex layers of post-translational regulation of HSFs that integrate the metabolic state of the cell with stress biology, and in doing so control fundamental aspects of the health of the proteome and ageing.

Senast uppdaterad 2019-19-10 vid 03:58